Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima—Peru

This study was performed to investigate the role of dysglycemia on genetic diversity Mycobacterium tuberculosis (MTB) among pulmonary (TB) patients build scientific evidence about possible mechanisms TB transmission. MTB isolates obtained affected by from health care facilities North Lima—Peru, were analyzed using whole genome sequencing and 24-locus mycobacterial interspersed repetitive-unit -variable-number tandem repeats (MIRU-VNTR). Subsequently, clinical epidemiological characteristics associated with clustering, lineages comorbid conditions. The analysis carried out 112 various centers in Lima, 17 (15%) had diabetes mellitus (DM) 33 (29%) pre-diabetes (PDM). Latin American-Mediterranean, Haarlem Beijing most frequent found those patients. Previous (adjusted odds ratio [aOR] = 3.65; 95%CI: 1.32–17.81), age (aOR 1.12; 1.03–1.45) lineage 3.53; 1.08–13.2) TB-DM comorbidity. Alcoholism 2.92; 1.10–8.28), 1.05; 1.03–1.12) 2.54; 1.04–6.51) TB-PDM independently comorbidities, respectively. Although these findings may be surprising, we must cautious suggest that could a highly clustering predisposition related serious impact severity disease, which requires further research.